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IGF-1 LR3 Reconstitution Calculator

A long-acting analog of insulin-like growth factor-1 studied in IGF-axis research. This page works out concentration, volume per measured amount, syringe units and preparations per vial for a reconstituted IGF-1 LR3 preparation, plus the mass-to-molar conversions for its stated molecular weight. Everything runs in your browser; nothing is transmitted or stored.

Also referenced as: Long R3 IGF-1, LR3-IGF-1

IGF-1 analog (Long R3 IGF-1 variant)MW Approximately 9111 g/mol
For research and educational purposes only. This is a unit-conversion tool for laboratory reference. It is not medical advice, not a dosing recommendation, and not an instruction for human use.

Inputs

Results

Concentration
2.5 mg/mL (2,500 mcg/mL)
Per syringe unit
25 mcg per unit
Volume per preparation
0.1 mL
Syringe units to draw
10 units
Preparations per vial
20 preparations

Worked example: a 5 mg vial reconstituted with 2 mL of bacteriostatic water. Change any input to recalculate.

A unit-conversion reference for laboratory work. Not a dosing recommendation and not an instruction for human use.

The pre-filled example, step by step

The inputs above are the neutral reference preparation this site uses everywhere the calculator appears: a 5 mg vial, 2 mL of bacteriostatic water, and a 250 mcg target amount. They are not a property of IGF-1 LR3 and not an amount anyone should draw — they exist so the arithmetic is visible before you change anything.

  1. Concentration. 5 mg ÷ 2 mL = 2.5 mg/mL (2,500 mcg/mL), which for IGF-1 LR3 is approximately 0.2744 mM at its stated molecular weight.
  2. Per syringe unit. A U-100 syringe divides 1 mL into 100 units, so one unit holds 2,500 mcg ÷ 100 = 25 mcg.
  3. Volume for the 250 mcg target. 250 mcg ÷ 2,500 mcg/mL = 0.1 mL, or 10 units on that syringe.
  4. Preparations per vial. 5,000 mcg ÷ 250 mcg = 20 preparations.

Arithmetic on a laboratory preparation, shown as a unit-conversion reference. Not medical advice, not a dosing recommendation, not an instruction for human use. The full derivation, and why the diluent volume is a choice rather than a constant, is on the main reconstitution calculator.

Mass and molar equivalents for IGF-1 LR3

Derived from the molecular weight recorded on the IGF-1 LR3 entry: Approximately 9111 g/mol — the entry states this as an approximate figure, so the equivalents below are approximate too. Concentration in molar units is what an in-vitro protocol is usually specified in.

Mass to molar conversions for IGF-1 LR3 at its stated molecular weight.
QuantityMolar equivalent
1 mg of IGF-1 LR3109.8 nmol (0.1098 µmol)
1 mcg of IGF-1 LR30.1098 nmol
A 1 mg/mL solution0.1098 mM (109.8 µM)

Molar amount = mass ÷ molecular weight. Figures are shown to four significant digits and are a unit conversion, not a measurement.

Reconstitution recorded for IGF-1 LR3

Lyophilized; typically reconstituted with bacteriostatic water or dilute acetic acid for research use

Quoted from the IGF-1 LR3 entry. Amounts reported in the research literature for this compound are documented on that entry, under the disclaimer they belong with — they are not reproduced next to a calculator. Read the full IGF-1 LR3 entry.

Handling questions for IGF-1 LR3

What is IGF-1 LR3?

IGF-1 LR3 (Long R3 IGF-1) is an 83-amino-acid analog of insulin-like growth factor-1 with an arginine substituted at position 3 and a 13-amino-acid N-terminal extension. It is an IGF-1 receptor agonist engineered for very low IGF-binding-protein affinity and greatly extended stability.

Why does IGF-1 LR3 have such an extended half-life?

The Arg3 substitution plus the N-terminal extension sharply lower its affinity for IGF-binding proteins while improving metabolic stability, so the peptide circulates far longer than native IGF-1. The research literature reports it is roughly three times more potent than native IGF-1.

Answers are published on the IGF-1 LR3 entry. Educational summaries of research-literature context, not medical advice.

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